Androstenedione production and interconversion rates measured in peripheral blood and studies on the possible site of its conversion to testosterone.
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چکیده
منابع مشابه
Androstenedione and its conversion to plasma testosterone in congenital adrenal hyperplasia.
The plasma concentration, production rate, and conversion ratio of androstenedione and testosterone were studied in seven children with congenital adrenal hyperplasia (CAH) of the 21-hydroxylase type. Plasma androstenedione and testosterone measured by double isotope derivative assay and estimated blood production rates were manyfold increased in the untreated state, markedly suppressed with gl...
متن کاملSites of in vivo extraction and interconversion of testosterone and androstenedione in dogs.
The interconversion and extraction of testosterone and androstenedione across and within different tissues or areas have been studied by the constant infusion technique. The results were calculated using the (3)H/(14)C ratios and radioactive concentrations of testosterone and androstenedione obtained from afferent and efferent blood and tissues at equilibrium. In each tissue studied, the interc...
متن کاملSplanchnic extraction and interconversion of testosterone and androstenedione in man.
A constant infusion of (3)H-testosterone and (14)C-androstenedione was administered to four human subjects, two males and two females, until the concentrations of radioactive testosterone and androstenedione in systemic plasma became constant. At that time the concentrations of radioactive testosterone and androstenedione in hepatic vein plasma were determined. Splanchnic extraction of testoste...
متن کاملConversion of blood androgens to estrogens in normal adult men and women.
Continuous infusions of Delta(4)-androstenedione-7-(3)H and testosterone-7-(3)H have been used to demonstrate that these androgens are converted to estrone and 17beta-estradiol, and contribute to the circulating blood levels of these estrogens in normal males and females. The conversion ratio (ratio of concentrations of radioactivity of free product steroid [chi(-PRO)] and free precursor steroi...
متن کاملAndrogen-Estrogen Production Rates in Postmenopausal Women with Breast Cancer1
In an attempt to define the hormonal environment of women with breast cancer, we examined the blood pro duction rates of androstenedione and its contributory role as a prehormone of estrone in a group of 46 postmenopausal women with advanced metastatic breast cancer. Androstenedione blood production rates averaged 1.85 mg/day and were not significantly different from 9 agematched women with oth...
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عنوان ژورنال:
- The Journal of clinical investigation
دوره 45 3 شماره
صفحات -
تاریخ انتشار 1966